Peptide reference
Kisspeptin
Metastin ·KISS1 ·Kisspeptin-54 ·Kisspeptin-10 ·KP-54 ·KP-10
What cited sources report about kisspeptin
Kisspeptin is an endogenous neuropeptide encoded by the KISS1 gene, secreted primarily by hypothalamic neurons, and signaling through the GPR54 (KISS1R) receptor on gonadotropin-releasing hormone neurons. Synthetic fragments — particularly kisspeptin-54 (KP-54) and kisspeptin-10 (KP-10) — have been investigated in human reproductive endocrinology. As of the cited literature, kisspeptin has no FDA-approved indication and no marketing authorization in any major jurisdiction. The summaries below report what individual cited sources state; this page does not assert claims beyond what those sources report.
Velmurugan et al. (2025) — Current Medicinal Chemistry
A systematic review that screened the indexed literature and identified 29 interventional clinical trials of kisspeptin across amenorrhea, puberty, fertility, lactation, and HPO-axis probing protocols. The authors documented the GPR54 mechanism, summarized adverse-event profiles as generally mild, and noted that no completed phase-3 confirmatory program supports a marketing application in any jurisdiction.
Kisspeptin can be viewed as a multipurpose drug with considerably fewer side effects due to its effects simulating normal physiological processes in our body.
Abbara et al. (2015) — Journal of Clinical Endocrinology and Metabolism
A dose-finding phase-2 trial conducted by the Imperial College London group in 60 women at high risk of ovarian hyperstimulation syndrome during IVF. The investigators administered single subcutaneous doses of kisspeptin-54 (3.2-12.8 nmol/kg) 36 hours before oocyte retrieval and reported oocyte maturation in 95% of women, no cases of moderate-to-critical OHSS, and a clinical pregnancy rate of 53% per transfer.
Kisspeptin-54 is a promising approach to effectively and safely trigger oocyte maturation in women undergoing IVF treatment at high risk of developing OHSS.
PubChem CID 25240297 — National Center for Biotechnology Information
The PubChem compound record for Kisspeptin-10 lists the molecular formula C63H83N17O14 and identifies the entry as the C-terminal decapeptide of the KISS1 gene product, also known as metastin 45-54. The record aggregates synonyms (KP-10, metastin 45-54) and links to the underlying KISS1/metastin literature.
Coverage notes
Most published human data on kisspeptin originates from a small number of academic groups (notably Imperial College London/Hammersmith) and is dominated by physiology and IVF-trigger protocols using kisspeptin-54. No FDA-approved kisspeptin product exists, and the systematic review cited above did not identify a registered phase-3 program intended to support a marketing application. Endogenous KISS1 biology and oncology applications (under the alternative name “metastin”) are extensively published but lie outside the regulatory-status focus of this page.