Peptide reference
SNAP-8
Acetyl Octapeptide-3 ·Acetyl Glutamyl Octapeptide-3 ·Ac-EEMQRRADQ-NH2
What cited sources report about SNAP-8
SNAP-8 (acetyl octapeptide-3) is a synthetic acetylated octapeptide marketed as a cosmetic ingredient by Lipotec/Lubrizol and described in product literature as an elongation of the Argireline (acetyl hexapeptide-3) sequence. It is a cosmetic ingredient under US regulatory definitions and is not approved as a drug by the FDA, EMA, or other regulators cited in the whitelisted sources reviewed for this page. The summaries below report what individual cited sources state; this page does not assert claims beyond what those sources report.
Shin et al. (2024) — Annals of Dermatology
A 2024 clinical evaluation of a dual-active dissolving microneedle patch from a Korean device-development group enrolled volunteers and assessed wrinkle, elasticity, and hydration endpoints over 28 days. The patch matrix combined hyaluronic acid, L-ascorbic acid, and acetyl octapeptide-3 (SNAP-8). The investigators reported improvements in the measured endpoints and no adverse events, but the design did not isolate SNAP-8 as a single active and the trial enrolled a small population.
DA-MNP comprising hyaluronic acid (HA) polymer backbone, acetyl octapept[ide-3]
PubChem CID 71587832 — National Center for Biotechnology Information
The PubChem compound record for acetyl octapeptide-3 lists molecular formula C42H72N16O15S, consistent with an acetylated octapeptide extension of the Argireline (Ac-EEMQRR) hexapeptide sequence. The record indexes the entry under the trade name SNAP-8 and links to the underlying chemical literature.
Coverage notes
Coverage notes: cosmetic ingredient with limited peer-reviewed clinical data. The SNAP-8 PubMed footprint is sparse; the indexed clinical record cited above evaluated SNAP-8 only as part of a combination microneedle product. Most publicly available SNAP-8 “research” originates from manufacturer (Lipotec/Lubrizol) whitepapers, INCI dossiers, and cosmetic-industry trade publications that fall outside the whitelisted scientific-source set used for this page. Only two whitelisted sources were available for this page; this is a known coverage gap reflecting the underlying ingredient class rather than an editorial omission.